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The enzymes involved in lysine methylation had been first discovered to target histone and thus had been initially named histone methyltransferases and histone demethylases, following the naming mannequin for histone acetyltransferase and histone deacetylase.
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KMTs catalyze mono-, di-, or tri-methylation by transfering one, two, or three methyl teams, respectively, from S-adenosyl-L-methionine to the ε-amino group of a lysine residue.
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In each proteins, the walls of the lysine-binding channel are formed by hydrophobic residues that interact in van der Waals interactions with the lysine side chain (Determine 4b,c ).
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